Roles of fl-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling
| PAG Title | Roles of fl-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling |
| PAG ID | WIG000266 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | The binding of -arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kinases, including c-Src, Hck and c-Fgr (Src-TK), to the receptor-arrestin complex. Several signaling events have been reported to involve -arrestin-dependent Src recruitment. These include the regulation of clathrin-dependent 2-adrenergic receptor endocytosis by tyrosine phosphorylation of dynamin, Ras-dependent activation of the ERK1/2 MAP kinase cascade and stimulation of cell proliferation by 2-adrenergic and neurokinin NK1 receptors, and stimulation of chemokine CXCR1 receptor-mediated neutrophil degranulation |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,606 |
| Information Content | Rich |
| Other IDs | M111 |
| Base PAG ID | WIG000266 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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